MAP6

MAP6
Identifiers
Aliases	MAP6, MTAP6, N-STOP, STOP, MAP6-N, microtubule associated protein 6
External IDs	OMIM: 601783; MGI: 1201690; HomoloGene: 7850; GeneCards: MAP6; OMA:MAP6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	75,669,038 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,986,344 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; pituitary gland; ; bronchial epithelial cell; ; nucleus accumbens; ; ganglionic eminence; ; right uterine tube; ; Brodmann area 9; ; anterior pituitary; ; hypothalamus; ; caudate nucleus;
	Top expressed in
	neural layer of retina; ; visual cortex; ; superior frontal gyrus; ; lumbar spinal ganglion; ; primary visual cortex; ; pontine nuclei; ; dorsal tegmental nucleus; ; superior ganglion of vagus nerve; ; medial vestibular nucleus; ; arcuate nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; calmodulin binding; microtubule binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; Golgi apparatus; microtubule; cytoskeleton; membrane; axon; dendrite; transport vesicle membrane; cytoplasmic vesicle; cell projection; Golgi-associated vesicle; cis-Golgi network;
Biological process	lysosome localization; microtubule cytoskeleton organization; dendrite morphogenesis; cytoskeleton-dependent intracellular transport; positive regulation of axonogenesis; regulation of microtubule cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	4135
	17760
	ENSG00000171533
	ENSMUSG00000055407
	Q96JE9
	Q7TSJ2
	NM_033063; NM_207577
	NM_001043355; NM_001048167; NM_010837
	NP_149052; NP_997460
	NP_001036820; NP_001041632; NP_034967
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated protein 6 (MAP6) or stable tubule-only polypeptide (STOP or STOP protein) is a protein that in humans is encoded by the MAP6 gene.^[5]^[6]

This gene encodes a microtubule-associated protein (MAP). The encoded protein is a calmodulin binding, and calmodulin-regulated protein that is involved in microtubule stabilization.

MAP6 localization is present throughout neuronal maturation and axonal development.^[7] It protects microtubules under drug and cold induced depolymerization by reducing the shrinking rate and promoting rescue events. A deficit in MAP6 protein levels is characterized by behavioral impairments, most notably schizophrenia.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171533 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055407 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Andrieux A, Salin PA, Vernet M, Kujala P, Baratier J, Gory-Fauré S, et al. (September 2002). "The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders". Genes & Development. 16 (18): 2350–2364. doi:10.1101/gad.223302. PMC 187434. PMID 12231625.
^ "Entrez Gene: MAP6 microtubule-associated protein 6".
^ Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC (May 2017). "Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization". Neuron. 94 (4): 809–825.e7. doi:10.1016/j.neuron.2017.04.042. PMID 28521134. S2CID 5517794.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171533 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055407 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12231625-5] Andrieux A, Salin PA, Vernet M, Kujala P, Baratier J, Gory-Fauré S, et al. (September 2002). "The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders". Genes & Development. 16 (18): 2350–2364. doi:10.1101/gad.223302. PMC 187434. PMID 12231625.

[entrez-6] "Entrez Gene: MAP6 microtubule-associated protein 6".

[7] Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC (May 2017). "Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization". Neuron. 94 (4): 809–825.e7. doi:10.1016/j.neuron.2017.04.042. PMID 28521134. S2CID 5517794.

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