MAPK8

MAPK8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE, 3V3V, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4AWI, 4E73, 4G1W, 4HYS, 4HYU, 4IZY, 4L7F, 4QTD, 4UX9, 4YR8
Identifiers
Aliases	MAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 8
External IDs	OMIM: 601158; MGI: 1346861; HomoloGene: 56760; GeneCards: MAPK8; OMA:MAPK8 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	48,439,360 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	33,169,115 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; tendon of biceps brachii; ; Achilles tendon; ; stromal cell of endometrium; ; buccal mucosa cell; ; ventricular zone; ; islet of Langerhans; ; internal globus pallidus; ; gallbladder; ; epithelium of colon;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; barrel cortex; ; superior cervical ganglion; ; ganglionic eminence; ; perirhinal cortex; ; visual cortex; ; genital tubercle; ; piriform cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; MAP kinase activity; histone deacetylase binding; histone deacetylase regulator activity; protein serine/threonine kinase activity; protein binding; enzyme binding; ATP binding; JUN kinase activity; kinase activity;
Cellular component	cytosol; nucleoplasm; nucleus; mitochondrion; cytoplasm; neuron projection; axon; basal dendrite;
Biological process	phosphorylation; rhythmic process; response to stress; negative regulation of apoptotic process; negative regulation of protein binding; regulation of protein localization; Fc-epsilon receptor signaling pathway; JNK cascade; cellular response to mechanical stimulus; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of gene expression; JUN phosphorylation; regulation of DNA-binding transcription factor activity; peptidyl-serine phosphorylation; regulation of circadian rhythm; positive regulation of deacetylase activity; peptidyl-threonine phosphorylation; positive regulation of cyclase activity; cellular response to lipopolysaccharide; response to UV; regulation of macroautophagy; regulation of histone deacetylation; positive regulation of apoptotic process; neuron development; protein phosphorylation; cellular response to amino acid starvation; cellular response to reactive oxygen species; stress-activated MAPK cascade; cellular response to cadmium ion; regulation of DNA replication origin binding; response to mechanical stimulus; regulation of gene expression; intracellular signal transduction; cellular response to organic substance; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5599
	26419
	ENSG00000107643
	ENSMUSG00000021936
	P45983
	Q91Y86
NM_001278547; NM_001278548; NM_002750; NM_139046; NM_139049;
	NM_001323302; NM_001323320; NM_001323321; NM_001323322; NM_001323323; NM_001323324; NM_001323325; NM_001323326; NM_001323327; NM_001323328; NM_001323329; NM_001323330; NM_001323331
	NM_001310452; NM_001310453; NM_001310454; NM_016700
NP_001265476; NP_001265477; NP_001310231; NP_001310249; NP_001310250;
	NP_001310251; NP_001310252; NP_001310253; NP_001310254; NP_001310255; NP_001310256; NP_001310257; NP_001310258; NP_001310259; NP_001310260; NP_620634; NP_620637
	NP_001297381; NP_001297382; NP_001297383; NP_057909
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107643 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021936 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (April 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Cell. 76 (6): 1025–37. doi:10.1016/0092-8674(94)90380-8. PMID 8137421. S2CID 6797795.
^ Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J. 15 (11): 2760–70. doi:10.1002/j.1460-2075.1996.tb00636.x. PMC 450211. PMID 8654373.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107643 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021936 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8137421-5] Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (April 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Cell. 76 (6): 1025–37. doi:10.1016/0092-8674(94)90380-8. PMID 8137421. S2CID 6797795.

[pmid8654373-6] Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J. 15 (11): 2760–70. doi:10.1002/j.1460-2075.1996.tb00636.x. PMC 450211. PMID 8654373.

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