MAS1 oncogene

MAS1 oncogene
Identifiers
SymbolMAS1
NCBI gene4142
HGNC6899
OMIM165180
RefSeqNM_002377
UniProtP04201
Other data
LocusChr. 6 q24-q27
Search for
StructuresSwiss-model
DomainsInterPro
MAS1 oncogene-like
Identifiers
SymbolMAS1L
NCBI gene116511
HGNC13961
OMIM607235
RefSeqNM_052967
UniProtP35410
Other data
LocusChr. 6 p21
Search for
StructuresSwiss-model
DomainsInterPro

The MAS1 oncogene (MAS receptor) is a G protein-coupled receptor[1][2] which binds the angiotensin II metabolite angiotensin (1-7).[3][4] The MAS1 receptor, when activated by binding angiotensin-(1-7), opposes many of the effects of the angiotensin II receptor. Hence, MAS1 receptor agonists have similar therapeutic effects to angiotensin II receptor antagonists, including lowering of blood pressure.[5]

  1. ^ Nunes-Silva A, Rocha GC, Magalhaes DM, Vaz LN, Salviano de Faria MH, Simoes e Silva AC (November 2017). "Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System". Protein and Peptide Letters. 24 (9). Bentham Science Publishers Ltd.: 809–816. doi:10.2174/0929866524666170728151401. PMID 28758593. (2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2 (ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, antiproliferation, anti-hypertrophy, cardioprotective and renoprotective actions.
  2. ^ Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (June 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691. S2CID 29886272.
  3. ^ Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, et al. (July 2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8258–63. Bibcode:2003PNAS..100.8258S. doi:10.1073/pnas.1432869100. PMC 166216. PMID 12829792.
  4. ^ Santos RA, Ferreira AJ (March 2007). "Angiotensin-(1-7) and the renin-angiotensin system". Current Opinion in Nephrology and Hypertension. 16 (2): 122–8. doi:10.1097/MNH.0b013e328031f362. PMID 17293687. S2CID 32812104.
  5. ^ Santos RA, Ferreira AJ (2006). "Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist". Cardiovascular Drug Reviews. 24 (3–4): 239–46. doi:10.1111/j.1527-3466.2006.00239.x. PMID 17214600.