MBOAT

MBOAT
Identifiers
SymbolMBOAT
PfamPF03062
Pfam clanCL0517
InterProIPR004299
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
MBOAT_2
Identifiers
SymbolMBOAT_2
PfamPF13813
Pfam clanCL0517
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The MBOAT (membrane bound O-acyl transferase) family of membrane proteins is a family of various acyltransferase enzymes. All family members contain multiple transmembrane domains and most carry two conserved residues, a conserved histidine (His) embedded in a hydrophobic stretch of residues and an asparagine (Asn) or histidine within a more hydrophilic region some 30-50 residues upstream.[1]

MBOAT enzymes catalyze the transfer of an acyl group from an acyl-coenzyme or accessory protein to one of several different substrates. The family is found from bacteria to eukaryotes.[2]

The family may be grouped into three categories, according to function:

  1. enzymes involved in neutral lipid biosynthesis;
  2. enzymes involved in protein/peptide acylation;
  3. enzymes involved in phospholipid re-modelling.[3]
  1. ^ Hofmann K (March 2000). "A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling". Trends Biochem. Sci. 25 (3): 111–2. doi:10.1016/s0968-0004(99)01539-x. PMID 10694878.
  2. ^ Chang, C.C.Y., Sun, J. & Chang, TY. (2011). "Membrane-bound O-acyltransferases (MBOATs)". Front. Biol. 6 (3): 177. doi:10.1007/s11515-011-1149-z. S2CID 41626991.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Wang P, Wang Z, Dou Y, Zhang X, Wang M, Tian X (2013). "Genome-wide identification and analysis of membrane-bound O-acyltransferase (MBOAT) gene family in plants". Planta. 238 (5): 907–22. Bibcode:2013Plant.238..907W. doi:10.1007/s00425-013-1939-4. PMID 23928653. S2CID 1328304.