MCD peptide

The amino acid sequence of MCD peptide^[1]
Met - Cys - Ile - Cys - Lys - Asn - Gly - Lys - Pro - Leu - Pro - Gly - Phe - Ile - Gly - Lys - Ile - Cys - Arg - Lys - Ile - Cys - Met - Met - Gln - Gln -Thr - His(NH2)

Mast cell degranulating (MCD) peptide is a cationic 22-amino acid residue peptide, which is a component of the venom of the bumblebee (Megabombus pennsylvanicus). At low concentrations, MCD peptide can stimulate mast cell degranulation. At higher concentrations, it has anti-inflammatory properties. In addition, it is a potent blocker of voltage-sensitive potassium channels.

^ Argiolas, A; Herring, P; Pisano, JJ (1985). "Amino Acid Sequence of Bumblebee MCD Peptide: A New Mast Cell Degranulating Peptide From the Venom of the Bumblebee Megabombus pennsylvanicus". Peptides. 6 (3): 431–436. doi:10.1016/0196-9781(85)90410-3. PMID 2421265. S2CID 3858397.

[Argiolas1985-1] Argiolas, A; Herring, P; Pisano, JJ (1985). "Amino Acid Sequence of Bumblebee MCD Peptide: A New Mast Cell Degranulating Peptide From the Venom of the Bumblebee Megabombus pennsylvanicus". Peptides. 6 (3): 431–436. doi:10.1016/0196-9781(85)90410-3. PMID 2421265. S2CID 3858397.

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