MCL1

MCL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KBW, 2MHS, 2NL9, 2NLA, 2PQK, 3D7V, 3IO9, 3KJ0, 3KJ1, 3KJ2, 3KZ0, 3MK8, 3PK1, 3TWU, 3WIX, 3WIY, 4BPI, 4BPJ, 4HW2, 4HW3, 4HW4, 4OQ5, 4OQ6, 4WGI, 4WMR, 4WMS, 4WMT, 4WMU, 4WMV, 4WMW, 4WMX, 4ZBF, 4ZBI, 5FDO, 5FDR, 5FC4, 5C3F
Identifiers
Aliases	MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, myeloid cell leukemia 1, BCL2 family apoptosis regulator, BCL2 family apoptosis regulator, MCL1 apoptosis regulator, BCL2 family member
External IDs	OMIM: 159552; MGI: 101769; HomoloGene: 7413; GeneCards: MCL1; OMA:MCL1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,579,738 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,570,487 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; parietal pleura; ; mucosa of urinary bladder; ; saphenous vein; ; Epithelium of choroid plexus; ; epithelium of nasopharynx; ; mononuclear cell; ; monocyte; ; cardia; ; gallbladder;
	Top expressed in
	otic placode; ; saccule; ; stroma of bone marrow; ; mesenteric lymph nodes; ; granulocyte; ; left colon; ; conjunctival fornix; ; blood; ; right lung lobe; ; left lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	BH3 domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; membrane; Bcl-2 family protein complex; nucleoplasm; mitochondrial outer membrane; mitochondrial matrix; mitochondrion; nucleus; cytosol;
Biological process	regulation of apoptotic process; cell differentiation; response to cytokine; cellular homeostasis; multicellular organism development; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; apoptotic mitochondrial changes; extrinsic apoptotic signaling pathway in absence of ligand; cell fate determination; regulation of response to DNA damage stimulus; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of anoikis; apoptotic process; negative regulation of apoptotic process; protein transmembrane transport; negative regulation of autophagy; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of intrinsic apoptotic signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4170
	17210
	ENSG00000143384
	ENSMUSG00000038612
	Q07820
	P97287
	NM_182763; NM_001197320; NM_021960
	NM_008562
	NP_001184249; NP_068779; NP_877495
	NP_032588
	Wikidata
View/Edit Human	View/Edit Mouse

Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143384 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038612 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW (April 1993). "MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2". Proceedings of the National Academy of Sciences of the United States of America. 90 (8): 3516–3520. Bibcode:1993PNAS...90.3516K. doi:10.1073/pnas.90.8.3516. PMC 46331. PMID 7682708.
^ Craig RW, Jabs EW, Zhou P, Kozopas KM, Hawkins AL, Rochelle JM, et al. (September 1994). "Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease". Genomics. 23 (2): 457–463. doi:10.1006/geno.1994.1523. PMID 7835896.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143384 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038612 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7682708-5] Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW (April 1993). "MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2". Proceedings of the National Academy of Sciences of the United States of America. 90 (8): 3516–3520. Bibcode:1993PNAS...90.3516K. doi:10.1073/pnas.90.8.3516. PMC 46331. PMID 7682708.

[pmid7835896-6] Craig RW, Jabs EW, Zhou P, Kozopas KM, Hawkins AL, Rochelle JM, et al. (September 1994). "Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease". Genomics. 23 (2): 457–463. doi:10.1006/geno.1994.1523. PMID 7835896.

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