MCM2

MCM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UUZ, 5BNV, 5BNX, 5BO0, 5C3I, 5JA4
Identifiers
Aliases	MCM2, BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19, minichromosome maintenance complex component 2, DFNA70
External IDs	OMIM: 116945; MGI: 105380; HomoloGene: 3325; GeneCards: MCM2; OMA:MCM2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	127,622,436 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	88,875,762 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ventricular zone; ; embryo; ; ganglionic eminence; ; trabecular bone; ; bone marrow cells; ; gonad; ; gingival epithelium; ; appendix;
	Top expressed in
	tibiofemoral joint; ; mandibular prominence; ; maxillary prominence; ; epiblast; ; tail of embryo; ; somite; ; primitive streak; ; fetal liver hematopoietic progenitor cell; ; ventricular zone; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; histone binding; metal ion binding; DNA helicase activity; protein binding; enzyme binding; DNA replication origin binding; hydrolase activity; ATP binding; single-stranded DNA binding; single-stranded DNA helicase activity; 3'-5' DNA helicase activity;
Cellular component	cytoplasm; microtubule cytoskeleton; nucleoplasm; nuclear origin of replication recognition complex; chromatin; MCM complex; nucleus; cytosol; nucleolus;
Biological process	cellular response to interleukin-4; nucleosome assembly; G1 phase; DNA replication; DNA replication initiation; DNA unwinding involved in DNA replication; apoptotic process; cell cycle; cochlea development; G1/S transition of mitotic cell cycle; negative regulation of DNA helicase activity; double-strand break repair via break-induced replication; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; mitotic DNA replication initiation;
	Sources:Amigo / QuickGO
Orthologs
	4171
	17216
	ENSG00000073111
	ENSMUSG00000002870
	P49736
	P97310
	NM_004526
	NM_008564
	NP_004517
	NP_032590
	Wikidata
View/Edit Human	View/Edit Mouse

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073111 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002870 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem Biophys Res Commun. 177 (1): 395–400. doi:10.1016/0006-291X(91)91996-P. PMID 1710453.
^ Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet Cell Genet. 65 (4): 276–7. doi:10.1159/000133647. PMID 8258304.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073111 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002870 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1710453-5] Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V (Jul 1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle". Biochem Biophys Res Commun. 177 (1): 395–400. doi:10.1016/0006-291X(91)91996-P. PMID 1710453.

[pmid8258304-6] Mincheva A, Todorov I, Werner D, Fink TM, Lichter P (Jan 1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21". Cytogenet Cell Genet. 65 (4): 276–7. doi:10.1159/000133647. PMID 8258304.

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