 | This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these messages)
|
| MDR-NUDIX | |
|---|---|
 Consensus secondary structure and sequence conservation of MDR-NUDIX RNA | |
| Identifiers | |
| Symbol | MDR-NUDIX |
| Rfam | RF02918 |
| Other data | |
| RNA type | Cis-reg |
| SO | SO:0005836 |
| PDB structures | PDBe |
The MDR-NUDIX RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] The MDR-NUDIX motif is found in the poorly studied phylum TM7.
MDR-NUDIX motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. Indeed, the RNAs are upstream of multiple genes that encode non-homologous proteins. If all examples of the RNA were upstream of homologous genes, there is the possibility that the RNAs were conserved in that position simply by inheritance. The non-homology of the genes downstream of MDR-NUDIX RNAs makes this scenario less likely. Most MDR-NUDIX RNAs are located upstream of genes that encode multidrug resistance transporters or the NUDIX protein domain, which is a hydrolase of various nucleoside diphosphate derivatives.
- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.