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MELISA (Memory Lymphocyte Immunostimulation Assay) is a blood test that detects type IV hypersensitivity to metals, chemicals, environmental toxins and molds. Type IV hypersensitivity reactions, particularly to nickel, are well established and may affect 20% of the population.[1]
- ^ Silverberg N, Pelletier J, Jacob S, Schneider L. Nickel allergic contact dermatitis: identification, treatment, and prevention. Pediatrics 2020; 145. https://doi.org/10.1542/peds.2020-0628.