MEPE

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Osteoregulin
Osteoregulin
Identifiers
Symbol	Osteoregulin
Pfam	PF07175
InterPro	IPR009837
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

MEPE
Identifiers
Aliases	MEPE, OF45, matrix extracellular phosphoglycoprotein
External IDs	OMIM: 605912; MGI: 2137384; HomoloGene: 10623; GeneCards: MEPE; OMA:MEPE - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,846,814 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,486,477 bp
RNA expression pattern
	Top expressed in
	tibia; ; periodontal fiber; ; trabecular bone; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 23; ; Brodmann area 9; ; prefrontal cortex; ; middle temporal gyrus; ; superior frontal gyrus;
	Top expressed in
	body of femur; ; tibiofemoral joint; ; cochlea; ; fossa; ; vestibular labyrinth; ; vestibular sensory epithelium; ; efferent ductule; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent; protein binding; extracellular matrix protein binding;
Cellular component	extracellular region; endoplasmic reticulum lumen; extracellular matrix;
Biological process	skeletal system development; biomineral tissue development; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	56955
	94111
	ENSG00000152595
	ENSMUSG00000053863
	Q9NQ76
	Q8K4L6
NM_001184694; NM_001184695; NM_001184696; NM_001184697; NM_001291183;
	NM_020203
	NM_053172
NP_001171623; NP_001171624; NP_001171625; NP_001171626; NP_001278112;
	NP_064588
	NP_444402
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.^[5]^[6] A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152595 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053863 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia". Genomics. 67 (1): 54–68. doi:10.1006/geno.2000.6235. PMID 10945470.
^ "Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)".
^ Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA (November 2000). "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes". J. Biol. Chem. 275 (46): 36172–80. doi:10.1074/jbc.M003622200. PMID 10967096.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152595 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053863 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10945470-5] Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000). "MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia". Genomics. 67 (1): 54–68. doi:10.1006/geno.2000.6235. PMID 10945470.

[entrez-6] "Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)".

[pmid10967096-7] Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA (November 2000). "Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes". J. Biol. Chem. 275 (46): 36172–80. doi:10.1074/jbc.M003622200. PMID 10967096.

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