MFGE8

MFGE8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L9L
Identifiers
Aliases	MFGE8, milk fat globule-EGF factor 8 protein, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, milk fat globule EGF and factor V/VIII domain containing
External IDs	OMIM: 602281; MGI: 102768; HomoloGene: 4334; GeneCards: MFGE8; OMA:MFGE8 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	88,913,468 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	78,798,808 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; right coronary artery; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; stromal cell of endometrium; ; left uterine tube; ; apex of heart; ; body of uterus;
	Top expressed in
	lactiferous gland; ; mesenteric lymph nodes; ; tunica media of zone of aorta; ; entorhinal cortex; ; choroid plexus of fourth ventricle; ; perirhinal cortex; ; lacrimal gland; ; ascending aorta; ; molar; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylserine binding; phosphatidylethanolamine binding; integrin binding; extracellular matrix structural constituent;
Cellular component	external side of plasma membrane; extrinsic component of plasma membrane; extracellular region; extracellular exosome; extracellular matrix; extracellular vesicle; membrane; extracellular space; endoplasmic reticulum lumen; collagen-containing extracellular matrix;
Biological process	phagocytosis, recognition; angiogenesis; positive regulation of phagocytosis; positive regulation of apoptotic cell clearance; phagocytosis, engulfment; cell adhesion; single fertilization; viral process; post-translational protein modification; apoptotic cell clearance;
	Sources:Amigo / QuickGO
Orthologs
	4240
	17304
	ENSG00000140545
	ENSMUSG00000030605
	Q08431
	P21956
	NM_001114614; NM_001310319; NM_001310320; NM_001310321; NM_005928
	NM_001045489; NM_008594
	NP_001108086; NP_001297248; NP_001297249; NP_001297250; NP_005919
	NP_001038954; NP_032620
	Wikidata
View/Edit Human	View/Edit Mouse

Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140545 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030605 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein".
^ Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G (January 1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics. 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140545 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030605 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein".

[pmid9027496-6] Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G (January 1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics. 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496.

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