MGAT5B

MGAT5B
Identifiers
Aliases	MGAT5B, GnT-IX, GnT-VB, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
External IDs	OMIM: 612441; MGI: 3606200; HomoloGene: 27821; GeneCards: MGAT5B; OMA:MGAT5B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,950,393 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,877,774 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; Brodmann area 9; ; oocyte; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen; ; prefrontal cortex; ; caudate nucleus; ; nucleus accumbens; ; amygdala;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; ventricular zone; ; ganglionic eminence; ; medial dorsal nucleus; ; superior colliculus; ; piriform cortex; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein binding; metal ion binding; glycosyltransferase activity; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity; manganese ion binding;
Cellular component	integral component of membrane; Golgi membrane; membrane; Golgi apparatus;
Biological process	protein glycosylation; protein N-linked glycosylation; protein O-linked glycosylation via serine;
	Sources:Amigo / QuickGO
Orthologs
	146664
	268510
	ENSG00000167889
	ENSMUSG00000043857
	Q3V5L5
	Q765H6
	NM_001199172; NM_144677; NM_198955
	NM_172948
	NP_001186101; NP_653278; NP_945193
	NP_766536
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B is an enzyme that in humans is encoded by the MGAT5B gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167889 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043857 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inamori K, Endo T, Gu J, Matsuo I, Ito Y, Fujii S, Iwasaki H, Narimatsu H, Miyoshi E, Honke K, Taniguchi N (Jan 2004). "N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan". J Biol Chem. 279 (4): 2337–2340. doi:10.1074/jbc.C300480200. PMID 14617637.
^ Kaneko M, Alvarez-Manilla G, Kamar M, Lee I, Lee JK, Troupe K, Zhang W, Osawa M, Pierce M (Nov 2003). "A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB)(1)". FEBS Lett. 554 (3): 515–519. doi:10.1016/S0014-5793(03)01234-1. PMID 14623122. S2CID 82207739.
^ "Entrez Gene: MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167889 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043857 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14617637-5] Inamori K, Endo T, Gu J, Matsuo I, Ito Y, Fujii S, Iwasaki H, Narimatsu H, Miyoshi E, Honke K, Taniguchi N (Jan 2004). "N-Acetylglucosaminyltransferase IX acts on the GlcNAc beta 1,2-Man alpha 1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan". J Biol Chem. 279 (4): 2337–2340. doi:10.1074/jbc.C300480200. PMID 14617637.

[pmid14623122-6] Kaneko M, Alvarez-Manilla G, Kamar M, Lee I, Lee JK, Troupe K, Zhang W, Osawa M, Pierce M (Nov 2003). "A novel beta(1,6)-N-acetylglucosaminyltransferase V (GnT-VB)(1)". FEBS Lett. 554 (3): 515–519. doi:10.1016/S0014-5793(03)01234-1. PMID 14623122. S2CID 82207739.

[entrez-7] "Entrez Gene: MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B".

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