MINK1

MINK1
Identifiers
Aliases	MINK1, B55, MAP4K6, MINK, YSK2, ZC3, hMINK, hMINKbeta, misshapen like kinase 1
External IDs	OMIM: 609426; MGI: 1355329; HomoloGene: 56762; GeneCards: MINK1; OMA:MINK1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,898,061 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,505,309 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; skin of leg; ; skin of abdomen; ; right hemisphere of cerebellum; ; dorsal motor nucleus of vagus nerve; ; nipple; ; olfactory bulb; ; inferior ganglion of vagus nerve; ; ventral tegmental area; ; mucosa of ileum;
	Top expressed in
	visual cortex; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; interventricular septum; ; piriform cortex; ; lip; ; cerebellar cortex; ; subiculum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; MAP kinase kinase kinase kinase activity;
Cellular component	cytoplasm; cytosol; postsynaptic membrane; Golgi apparatus; cell projection; postsynaptic density; membrane; plasma membrane; synapse; cell junction; axon; dendrite; extracellular exosome;
Biological process	actin cytoskeleton reorganization; regulation of cell migration; intracellular signal transduction; microvillus assembly; dendrite morphogenesis; phosphorylation; response to stress; positive regulation of JNK cascade; regulation of cell-matrix adhesion; regulation of AMPA receptor activity; multicellular organism development; protein phosphorylation; JNK cascade; regulation of cell-cell adhesion; protein autophosphorylation; chemical synaptic transmission; regulation of mitotic cell cycle; regulation of apoptotic process; neuron projection morphogenesis; MAPK cascade; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity; positive regulation of p38MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	50488
	50932
	ENSG00000141503
	ENSMUSG00000020827
	Q8N4C8
	Q9JM52
	NM_001024937; NM_015716; NM_153827; NM_170663; NM_001321236
	NM_001045959; NM_001045964; NM_016713; NM_176893
	NP_001020108; NP_001308165; NP_056531; NP_722549; NP_733763
NP_001039424; NP_001039429; NP_057922; NP_795712; NP_001390484;
	NP_001390485; NP_001390486
	Wikidata
View/Edit Human	View/Edit Mouse

Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141503 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020827 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dan I, Watanabe NM, Kobayashi T, Yamashita-Suzuki K, Fukagaya Y, Kajikawa E, Kimura WK, Nakashima TM, Matsumoto K, Ninomiya-Tsuji J, Kusumi A (Mar 2000). "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development". FEBS Letters. 469 (1): 19–23. doi:10.1016/S0014-5793(00)01247-3. PMID 10708748. S2CID 39793431.
^ Dan I, Watanabe NM, Kajikawa E, Ishida T, Pandey A, Kusumi A (Jul 2002). "Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution". Nucleic Acids Research. 30 (13): 2906–10. doi:10.1093/nar/gkf407. PMC 117062. PMID 12087176.
^ "Entrez Gene: MINK1 misshapen-like kinase 1 (zebrafish)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141503 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020827 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10708748-5] Dan I, Watanabe NM, Kobayashi T, Yamashita-Suzuki K, Fukagaya Y, Kajikawa E, Kimura WK, Nakashima TM, Matsumoto K, Ninomiya-Tsuji J, Kusumi A (Mar 2000). "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development". FEBS Letters. 469 (1): 19–23. doi:10.1016/S0014-5793(00)01247-3. PMID 10708748. S2CID 39793431.

[pmid12087176-6] Dan I, Watanabe NM, Kajikawa E, Ishida T, Pandey A, Kusumi A (Jul 2002). "Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution". Nucleic Acids Research. 30 (13): 2906–10. doi:10.1093/nar/gkf407. PMC 117062. PMID 12087176.

[entrez-7] "Entrez Gene: MINK1 misshapen-like kinase 1 (zebrafish)".

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