MKX

MKX
Identifiers
Aliases	MKX, C10orf48, IFRX, IRXL1, mohawk homeobox
External IDs	OMIM: 601332; MGI: 2687286; HomoloGene: 72239; GeneCards: MKX; OMA:MKX - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	27,746,060 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	7,004,780 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; endothelial cell; ; right coronary artery; ; prostate; ; popliteal artery; ; tibial arteries; ; testicle; ; stromal cell of endometrium; ; anterior pituitary; ; left coronary artery;
	Top expressed in
	hand; ; cumulus cell; ; somite; ; foot; ; genital tubercle; ; lacrimal gland; ; female urethra; ; tail of embryo; ; desmocranium; ; calvaria;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; muscle organ development; multicellular organism development; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	283078
	210719
	ENSG00000150051
	ENSMUSG00000061013
	Q8IYA7
	Q8BIA3
	NM_001242702; NM_173576
	NM_177595
	NP_001229631; NP_775847
	NP_808263
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Mohawk, also known as iroquois homeobox protein-like 1, is a protein that in humans is encoded by the MKX (mohawk homeobox) gene.^[5] MKX is a member of an Iroquois (IRX) family-related class of 'three-amino acid loop extension' (TALE) atypical homeobox proteins characterized by 3 additional amino acids in the loop region between helix I and helix II of the homeodomain.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150051 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061013 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: mohawk homeobox".
^ Anderson DM, Arredondo J, Hahn K, Valente G, Martin JF, Wilson-Rawls J, Rawls A (March 2006). "Mohawk is a novel homeobox gene expressed in the developing mouse embryo". Developmental Dynamics. 235 (3): 792–801. doi:10.1002/dvdy.20671. PMID 16408284. S2CID 29018840.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150051 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061013 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: mohawk homeobox".

[pmid16408284-6] Anderson DM, Arredondo J, Hahn K, Valente G, Martin JF, Wilson-Rawls J, Rawls A (March 2006). "Mohawk is a novel homeobox gene expressed in the developing mouse embryo". Developmental Dynamics. 235 (3): 792–801. doi:10.1002/dvdy.20671. PMID 16408284. S2CID 29018840.

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