Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene.[5] It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.[6] It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167965 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024142 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: MTOR associated protein".
- ^ "UniProtKB – Q9BVC4 (LST8_HUMAN)".
- ^ Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 Apr 2015). "mLST8 Promotes mTOR-Mediated Tumor Progression". PLOS ONE. 10 (4): e0119015. Bibcode:2015PLoSO..1019015K. doi:10.1371/journal.pone.0119015. PMC 4408021. PMID 25906254.