MLST8

MLST8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMLST8, GBL, GbetaL, LST8, POP3, WAT1, MTOR associated protein, LST8 homolog
External IDsOMIM: 612190; MGI: 1929514; HomoloGene: 6833; GeneCards: MLST8; OMA:MLST8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252463
NM_001252464
NM_001252465
NM_019988

RefSeq (protein)

NP_001239392
NP_001239393
NP_001239394
NP_064372

Location (UCSC)Chr 16: 2.2 – 2.21 MbChr 17: 24.69 – 24.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene.[5] It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.[6] It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167965Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024142Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MTOR associated protein".
  6. ^ "UniProtKB – Q9BVC4 (LST8_HUMAN)".
  7. ^ Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C (23 Apr 2015). "mLST8 Promotes mTOR-Mediated Tumor Progression". PLOS ONE. 10 (4): e0119015. Bibcode:2015PLoSO..1019015K. doi:10.1371/journal.pone.0119015. PMC 4408021. PMID 25906254.