MMP2

MMP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CK7, 1CXW, 1EAK, 1GEN, 1GXD, 1HOV, 1J7M, 1KS0, 1QIB, 1RTG, 3AYU
Identifiers
Aliases	MMP2, CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1, matrix metallopeptidase 2
External IDs	OMIM: 120360; MGI: 97009; HomoloGene: 3329; GeneCards: MMP2; OMA:MMP2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	55,506,691 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	93,580,048 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gallbladder; ; gastric mucosa; ; canal of the cervix; ; skin of hip; ; smooth muscle tissue; ; epithelium of colon; ; right lung; ; left uterine tube; ; Descending thoracic aorta;
	Top expressed in
	vestibular sensory epithelium; ; external carotid artery; ; calvaria; ; internal carotid artery; ; body of femur; ; condyle; ; vas deferens; ; conjunctival fornix; ; fossa; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding; peptidase activity; protein binding; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; serine-type endopeptidase activity;
Cellular component	cytoplasm; membrane; plasma membrane; sarcomere; extracellular region; mitochondrion; nucleus; extracellular matrix; extracellular space; collagen-containing extracellular matrix;
Biological process	intramembranous ossification; response to hypoxia; endodermal cell differentiation; ephrin receptor signaling pathway; skeletal system morphogenesis; extracellular matrix disassembly; bone trabecula formation; proteolysis; angiogenesis; positive regulation of innate immune response; collagen catabolic process; cellular response to amino acid stimulus; face morphogenesis; embryo implantation; blood vessel maturation; positive regulation of vascular associated smooth muscle cell proliferation; cytokine-mediated signaling pathway; extracellular matrix organization; cellular response to reactive oxygen species; positive regulation of smooth muscle cell proliferation; tissue remodeling; response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	4313
	17390
	ENSG00000087245
	ENSMUSG00000031740
	P08253
	P33434
	NM_004530; NM_001127891; NM_001302508; NM_001302509; NM_001302510
	NM_008610
	NP_001121363; NP_001289437; NP_001289438; NP_001289439; NP_004521
	NP_032636
	Wikidata
View/Edit Human	View/Edit Mouse

72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.^[5] The MMP2 gene is located on chromosome 16 at position 12.2.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087245 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031740 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Devarajan P, Johnston JJ, Ginsberg SS, et al. (December 1992). "Structure and expression of neutrophil gelatinase cDNA. Identity with type IV collagenase from HT1080 cells". J. Biol. Chem. 267 (35): 25228–32. doi:10.1016/S0021-9258(19)74029-0. PMID 1460022.
^ "MMP2 gene". Genetics Home Reference. Retrieved 19 May 2015.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087245 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031740 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1460022-5] Devarajan P, Johnston JJ, Ginsberg SS, et al. (December 1992). "Structure and expression of neutrophil gelatinase cDNA. Identity with type IV collagenase from HT1080 cells". J. Biol. Chem. 267 (35): 25228–32. doi:10.1016/S0021-9258(19)74029-0. PMID 1460022.

[6] "MMP2 gene". Genetics Home Reference. Retrieved 19 May 2015.

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