MMP9

MMP9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GKC, 1GKD, 1ITV, 1L6J, 2OVX, 2OVZ, 2OW0, 2OW1, 2OW2, 4H1Q, 4H2E, 4H3X, 4H82, 4HMA, 4JIJ, 4JQG, 4WZV, 4XCT, 5CUH, 5I12
Identifiers
Aliases	MMP9, CLG4B, GELB, MANDP2, MMP-9, 92 kDa type IV collagenase, 92 kDa gelatinase, gelatinase B, matrix metallopeptidase 9
External IDs	OMIM: 120361; MGI: 97011; HomoloGene: 3659; GeneCards: MMP9; OMA:MMP9 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,008,908 bp[1] End 46,016,561 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 85.27 cM Start 164,782,700 bp[2] End 164,797,770 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber trabecular bone tibia bone marrow bone marrow cells appendix blood cartilage tissue skin of hip lymph node Top expressed in granulocyte tibiofemoral joint body of femur Dermatocranium mandible bones of pectoral girdle molar ankle rib trophoblast giant cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function collagen binding zinc ion binding metal ion binding peptidase activity protein binding identical protein binding hydrolase activity metallopeptidase activity endopeptidase activity serine-type endopeptidase activity metalloendopeptidase activity Cellular component extracellular matrix extracellular exosome extracellular space tertiary granule lumen ficolin-1-rich granule lumen extracellular region collagen-containing extracellular matrix Biological process skeletal system development negative regulation of cation channel activity positive regulation of protein phosphorylation endodermal cell differentiation negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ossification negative regulation of intrinsic apoptotic signaling pathway ephrin receptor signaling pathway extracellular matrix disassembly negative regulation of apoptotic process proteolysis macrophage differentiation positive regulation of keratinocyte migration positive regulation of apoptotic process collagen catabolic process positive regulation of release of cytochrome c from mitochondria positive regulation of receptor binding positive regulation of DNA binding positive regulation of epidermal growth factor receptor signaling pathway embryo implantation leukocyte migration positive regulation of vascular associated smooth muscle cell proliferation extracellular matrix organization positive regulation of cell migration neutrophil degranulation cellular response to reactive oxygen species cellular response to cadmium ion cytokine-mediated signaling pathway regulation of neuroinflammatory response negative regulation of epithelial cell differentiation involved in kidney development response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4318 17395 Ensembl ENSG00000100985 ENSMUSG00000017737 UniProt P14780 P41245 RefSeq (mRNA) NM_004994 NM_013599 RefSeq (protein) NP_004985 NP_038627 Location (UCSC) Chr 20: 46.01 – 46.02 Mb Chr 2: 164.78 – 164.8 Mb PubMed search [3] [4]
Wikidata
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Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene^[5] encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.^[6]