MPP2

MPP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E7K
Identifiers
Aliases	MPP2, DLG2, membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2
External IDs	OMIM: 600723; MGI: 1858257; HomoloGene: 3920; GeneCards: MPP2; OMA:MPP2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	43,909,711 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,979,341 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; prefrontal cortex; ; right hemisphere of cerebellum; ; right frontal lobe; ; hypothalamus; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; substantia nigra;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; subiculum; ; superior frontal gyrus; ; piriform cortex; ; dorsomedial hypothalamic nucleus; ; neural layer of retina; ; superior colliculus; ; primary motor cortex; ; anterior amygdaloid area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanylate kinase activity; protein binding;
Cellular component	integral component of plasma membrane; postsynaptic density; dendrite membrane; dendritic spine; dendritic shaft; cytoplasm; cytoskeleton; plasma membrane; membrane; dendrite; dendritic spine membrane; cell projection;
Biological process	signal transduction; GMP metabolic process; GDP metabolic process; protein homooligomerization; excitatory postsynaptic potential; long-term potentiation;
	Sources:Amigo / QuickGO
Orthologs
	4355
	50997
	ENSG00000108852
	ENSMUSG00000017314
	Q14168
	Q9WV34
NM_001278370; NM_001278371; NM_001278372; NM_001278373; NM_001278374;
	NM_001278375; NM_001278376; NM_001278381; NM_005374
	NM_016695; NM_001356324
NP_001265299; NP_001265300; NP_001265301; NP_001265302; NP_001265303;
	NP_001265304; NP_001265305; NP_001265310; NP_005365
	NP_057904; NP_001343253
	Wikidata
View/Edit Human	View/Edit Mouse

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.^[5]^[6]

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108852 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017314 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995). "A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A". Genomics. 28 (1): 25–31. doi:10.1006/geno.1995.1101. PMID 7590743.
^ ^a ^b "Entrez Gene: MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108852 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017314 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7590743-5] Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995). "A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A". Genomics. 28 (1): 25–31. doi:10.1006/geno.1995.1101. PMID 7590743.

[entrez-6] "Entrez Gene: MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)".

[1]

[2]

[3]

[4]

[5]

[6]