MPP2

MPP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMPP2, DLG2, membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2
External IDsOMIM: 600723; MGI: 1858257; HomoloGene: 3920; GeneCards: MPP2; OMA:MPP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016695
NM_001356324

RefSeq (protein)

NP_057904
NP_001343253

Location (UCSC)Chr 17: 43.88 – 43.91 MbChr 11: 101.95 – 101.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.[5][6]

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108852Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017314Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995). "A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A". Genomics. 28 (1): 25–31. doi:10.1006/geno.1995.1101. PMID 7590743.
  6. ^ a b "Entrez Gene: MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)".