MSH3

MSH3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3THW, 3THX, 3THY, 3THZ
Identifiers
Aliases	MSH3, DUP, MRP1, mutS homolog 3, FAP4
External IDs	OMIM: 600887; MGI: 109519; HomoloGene: 1829; GeneCards: MSH3; OMA:MSH3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.1 Start 80,654,652 bp[1] End 80,876,815 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 C3|13 47.63 cM Start 92,348,380 bp[2] End 92,491,511 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell mucosa of paranasal sinus secondary oocyte cardia gonad testicle renal medulla external globus pallidus subthalamic nucleus Achilles tendon Top expressed in zygote tail of embryo spermatocyte secondary oocyte genital tubercle primary oocyte ventricular zone epiblast spermatid neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding DNA binding protein homodimerization activity mismatched DNA binding dinucleotide insertion or deletion binding oxidized purine DNA binding single-stranded DNA binding protein binding enzyme binding dinucleotide repeat insertion binding ATP binding single guanine insertion binding guanine/thymine mispair binding Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding damaged DNA binding ATP-dependent activity, acting on DNA single thymine insertion binding DNA insertion or deletion binding Cellular component MutSbeta complex membrane nucleoplasm nucleus mismatch repair complex Biological process cellular response to DNA damage stimulus maintenance of DNA repeat elements positive regulation of helicase activity negative regulation of DNA recombination DNA mismatch repair DNA repair somatic recombination of immunoglobulin gene segments meiotic mismatch repair removal of nonhomologous ends mitotic recombination reciprocal meiotic recombination replication fork arrest Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4437 17686 Ensembl ENSG00000113318 ENSMUSG00000014850 UniProt P20585 P13705 RefSeq (mRNA) NM_002439 NM_010829 NM_001311120 RefSeq (protein) NP_002430 NP_001298049 NP_034959 Location (UCSC) Chr 5: 80.65 – 80.88 Mb Chr 13: 92.35 – 92.49 Mb PubMed search [3] [4]
Wikidata
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DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellites during DNA synthesis. Deficient capacity for MMR is found in approximately 15% of colorectal cancers, and somatic mutations in the MSH3 gene can be found in nearly 50% of MMR-deficient colorectal cancers.^[5]