MT-ND6

ND6
Identifiers
Aliases	ND6, MTMT-NADH dehydrogenase, subunit 6 (complex I), NADH dehydrogenase subunit 6
External IDs	OMIM: 516006; MGI: 102495; HomoloGene: 5022; GeneCards: ND6; OMA:ND6 - orthologs
Gene location (Human)
Chr.	Mitochondrial DNA (human)
End	14,673 bp
Gene location (Mouse)
Chr.	Mitochondrial DNA (mouse)
End	14,070 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; left uterine tube; ; right uterine tube; ; right auricle; ; granulocyte; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; amygdala; ; fundus;
	Top expressed in
	neural layer of retina; ; adrenal gland; ; hypothalamus; ; striatum of neuraxis; ; bone marrow; ; hippocampus proper; ; superior frontal gyrus; ; human kidney; ; cerebellar cortex; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity; oxidoreductase activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; respirasome; membrane; mitochondrial membranes; mitochondrion;
Biological process	response to cocaine; response to nicotine; response to hydrogen peroxide; mitochondrial respiratory chain complex I assembly; mitochondrial electron transport, NADH to ubiquinone;
	Sources:Amigo / QuickGO
Orthologs
	4541
	17722
	ENSG00000198695
	ENSMUSG00000064368
	P03923
	P03925
	n/a
	n/a
	n/a
	NP_904339
	Wikidata
View/Edit Human	View/Edit Mouse

MT-ND6 is a gene of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain 6 protein (ND6).^[5] The ND6 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.^[6] Variations in the human MT-ND6 gene are associated with Leigh's syndrome, Leber's hereditary optic neuropathy (LHON) and dystonia.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198695 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000064368 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MT-ND6 NADH dehydrogenase subunit 6".
^ Donald Voet; Judith G. Voet; Charlotte W. Pratt (2013). "18". Fundamentals of biochemistry : life at the molecular level (4th ed.). Hoboken, NJ: Wiley. pp. 581–620. ISBN 9780470547847.
^ "MT-ND6". Genetics Home Reference. U.S. National Library of Medicine. Retrieved 23 March 2015.