The MTV Europe Music Award for Best Collaboration was first awarded in 2015. The award was not given from 2016–2018, making a return in 2019. Karol G is the only artist to win this award twice; "Tusa" with Nicki Minaj in 2020 and "TQG" with Shakira in 2023.
The following is a list of the MTV Europe Music Award winners and nominees for Best Collaboration.