MYF5

MYF5
Identifiers
Aliases	MYF5, bHLHc2, myogenic factor 5, EORVA
External IDs	OMIM: 159990; MGI: 97252; HomoloGene: 4085; GeneCards: MYF5; OMA:MYF5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.31 Start 80,716,912 bp[1] End 80,719,671 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D1|10 55.95 cM Start 107,318,769 bp[2] End 107,321,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii muscle of thigh gastrocnemius muscle skeletal muscle tissue deltoid muscle tibialis anterior muscle body of tongue exocrine gland salivary gland male reproductive gland Top expressed in myotome urethra male urethra human fetus extraocular muscle muscle layer of urethra soleus muscle muscle of upper limb internal carotid artery temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding protein dimerization activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding E-box binding protein binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm RNA polymerase II transcription regulator complex nucleus Biological process somitogenesis embryonic skeletal system morphogenesis cell differentiation regulation of transcription, DNA-templated muscle organ morphogenesis ossification positive regulation of muscle cell differentiation regulation of transcription by RNA polymerase II muscle cell fate commitment muscle organ development extracellular matrix organization transcription by RNA polymerase II positive regulation of skeletal muscle fiber development transcription, DNA-templated regulation of cell-matrix adhesion multicellular organism development positive regulation of myoblast fusion positive regulation of myoblast differentiation muscle tissue morphogenesis skeletal muscle cell differentiation camera-type eye development skeletal muscle tissue development cartilage condensation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4617 17877 Ensembl ENSG00000111049 ENSMUSG00000000435 UniProt P13349 P24699 RefSeq (mRNA) NM_005593 NM_008656 RefSeq (protein) NP_005584 NP_032682 Location (UCSC) Chr 12: 80.72 – 80.72 Mb Chr 10: 107.32 – 107.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. ^[5] It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6).^[6] This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice).^[7] It functions during that time to commit myogenic precursor cells to become skeletal muscle. In fact, its expression in proliferating myoblasts has led to its classification as a determination factor. Furthermore, Myf5 is a master regulator of muscle development, possessing the ability to induce a muscle phenotype upon its forced expression in fibroblastic cells.^[8]