MYH7

MYH7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DTP, 4DB1, 4P7H, 4XA1, 4XA3, 4XA4, 4XA6, 4PA0, 5CHX, 5CJ0, 5CJ4, 5CJ1, 2FXO, 2FXM
Identifiers
Aliases	MYH7, CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM, myosin, heavy chain 7, cardiac muscle, beta, myosin heavy chain 7
External IDs	OMIM: 160760; MGI: 2155600; HomoloGene: 68044; GeneCards: MYH7; OMA:MYH7 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 23,412,740 bp[1] End 23,435,660 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.01 cM Start 55,208,141 bp[2] End 55,232,083 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh Skeletal muscle tissue of biceps brachii gastrocnemius muscle right ventricle left ventricle glutes triceps brachii muscle myocardium of left ventricle vastus lateralis muscle Top expressed in soleus muscle atrioventricular valve endocardial cushion ankle plantaris muscle cardiac muscle tissue of left ventricle extraocular muscle thoracic diaphragm intercostal muscle internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calmodulin binding protein binding actin binding cytoskeletal motor activity ATP binding ATPase activity microfilament motor activity actin filament binding microtubule motor activity microtubule binding Cellular component cytoplasm stress fiber Z discdkac myosin filament myosin complex muscle myosin complex myofibril sarcomere Biological process cardiac muscle contraction adult heart development transition between fast and slow fiber regulation of the force of heart contraction skeletal muscle contraction regulation of slow-twitch skeletal muscle fiber contraction regulation of heart rate ventricular cardiac muscle tissue morphogenesis ATP metabolic process muscle filament sliding striated muscle contraction regulation of the force of skeletal muscle contraction muscle contraction cardiac muscle hypertrophy in response to stress microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4625 140781 Ensembl ENSG00000092054 ENSMUSG00000053093 UniProt P12883 Q91Z83 RefSeq (mRNA) NM_000257 NM_080728 NM_001361607 RefSeq (protein) NP_000248 NP_542766 NP_001348536 Location (UCSC) Chr 14: 23.41 – 23.44 Mb Chr 14: 55.21 – 55.23 Mb PubMed search [3] [4]
Wikidata
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MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers).^[5] This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thick filament that forms the sarcomeres in cardiac muscle and plays a major role in cardiac muscle contraction.^[6]