MYL1

MYL1
Identifiers
Aliases	MYL1, MLC1F, MLC3F, myosin light chain 1, MYOFTA, MLC1, MLC1/3, MLC-1
External IDs	OMIM: 160780; MGI: 97269; HomoloGene: 23194; GeneCards: MYL1; OMA:MYL1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	210,315,174 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	66,984,563 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; gastrocnemius muscle; ; triceps brachii muscle; ; muscle of thigh; ; tibialis anterior muscle; ; thoracic diaphragm; ; quadriceps femoris muscle; ; vastus lateralis muscle;
	Top expressed in
	quadriceps femoris muscle; ; skeletal muscle tissue; ; muscle of thigh; ; zone of skin; ; esophagus; ; lip; ; white adipose tissue; ; synovial joint; ; ankle joint; ; heart;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; structural constituent of muscle;
Cellular component	contractile fiber; cytosol; muscle myosin complex; myofibril; sarcomere; myosin complex;
Biological process	muscle contraction; cardiac muscle contraction; muscle filament sliding;
	Sources:Amigo / QuickGO
Orthologs
	4632
	17901
	ENSG00000168530
	ENSMUSG00000061816
	P05976
	P05977
	NM_079422; NM_079420
	NM_001113387; NM_021285
	NP_524144; NP_524146
	NP_001106858; NP_067260
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.^[5]^[6]^[7]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168530 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061816 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
^ Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J (Mar 1988). "Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter". Hum Genet. 78 (1): 65–70. doi:10.1007/BF00291237. PMID 3422212. S2CID 24782863.
^ ^a ^b "Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168530 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061816 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2304459-5] Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.

[pmid3422212-6] Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J (Mar 1988). "Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter". Hum Genet. 78 (1): 65–70. doi:10.1007/BF00291237. PMID 3422212. S2CID 24782863.

[entrez-7] "Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast".

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