MYL3

MYL3
Identifiers
Aliases	MYL3, CMH8, MLC1SB, MLC1V, VLC1, MLC-lV/sb, VLCl, myosin light chain 3
External IDs	OMIM: 160790; MGI: 97268; HomoloGene: 20099; GeneCards: MYL3; OMA:MYL3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,882,172 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	110,598,866 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right ventricle; ; muscle of thigh; ; myocardium of left ventricle; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; glutes;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; cardiac muscles; ; atrioventricular valve; ; soleus muscle; ; cardiac muscle tissue of left ventricle; ; endocardial cushion; ; right ventricle; ; plantaris muscle; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; structural constituent of muscle; cytoskeletal motor activity; actin monomer binding; myosin II heavy chain binding;
Cellular component	cytosol; muscle myosin complex; sarcomere; A band; I band; myosin complex;
Biological process	ventricular cardiac muscle tissue morphogenesis; regulation of striated muscle contraction; skeletal muscle tissue development; positive regulation of ATP-dependent activity; cardiac muscle contraction; regulation of the force of heart contraction; muscle filament sliding;
	Sources:Amigo / QuickGO
Orthologs
	4634
	17897
	ENSG00000160808
	ENSMUSG00000059741
	P08590
	P09542
	NM_000258
	NM_010859; NM_001364484
	NP_000249; NP_000249.1
	NP_034989; NP_001351413
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene.^[5]^[6]^[7] This cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial muscle (MYL4). Ventricular ELC is part of the myosin molecule and is important in modulating cardiac muscle contraction.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160808 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059741 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shi Q, Li RK, Mickle DA, Jackowski G (November 1992). "Analysis of the upstream regulatory region of human ventricular myosin light chain 1 gene". Journal of Molecular and Cellular Cardiology. 24 (11): 1221–9. doi:10.1016/0022-2828(92)93089-3. PMID 1479618.
^ Cohen-Haguenauer O, Barton PJ, Van Cong N, Cohen A, Masset M, Buckingham M, Frézal J (February 1989). "Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4)". Human Genetics. 81 (3): 278–82. doi:10.1007/bf00279004. PMID 2784124. S2CID 6703175.
^ "Entrez Gene: MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160808 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059741 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1479618-5] Shi Q, Li RK, Mickle DA, Jackowski G (November 1992). "Analysis of the upstream regulatory region of human ventricular myosin light chain 1 gene". Journal of Molecular and Cellular Cardiology. 24 (11): 1221–9. doi:10.1016/0022-2828(92)93089-3. PMID 1479618.

[pmid2784124-6] Cohen-Haguenauer O, Barton PJ, Van Cong N, Cohen A, Masset M, Buckingham M, Frézal J (February 1989). "Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4)". Human Genetics. 81 (3): 278–82. doi:10.1007/bf00279004. PMID 2784124. S2CID 6703175.

[entrez-7] "Entrez Gene: MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow".

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