MYL4

MYL4
Identifiers
Aliases	MYL4, ALC1, AMLC, GT1, PRO1957, myosin light chain 4
External IDs	OMIM: 160770; MGI: 97267; HomoloGene: 20558; GeneCards: MYL4; OMA:MYL4 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,223,679 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	104,595,753 bp
RNA expression pattern
	Top expressed in
	right auricle; ; cardiac muscle tissue of right atrium; ; apex of heart; ; vena cava; ; right ventricle; ; testicle; ; trabecular bone; ; left ventricle; ; blood; ; bone marrow;
	Top expressed in
	atrium; ; endocardial cushion; ; atrioventricular valve; ; aortic valve; ; internal carotid artery; ; human fetus; ; interventricular septum; ; right lung; ; right lung lobe; ; fossa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; actin filament binding; actin monomer binding; myosin II heavy chain binding;
Cellular component	cytosol; A band; myosin complex;
Biological process	positive regulation of ATP-dependent activity; cardiac muscle contraction; regulation of the force of heart contraction; muscle filament sliding;
	Sources:Amigo / QuickGO
Orthologs
	4635
	17896
	ENSG00000198336
	ENSMUSG00000061086
	P12829
	P09541
	NM_001002841; NM_002476
	NM_010858; NM_001355754; NM_001355755
	NP_001002841; NP_002467
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene.^[5]^[6] ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases.