MYLK

MYLK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQV, 2K0F, 2YR3
Identifiers
Aliases	MYLK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK, myosin light chain kinase, MMIHS, MMIHS1, MYLK-L
External IDs	OMIM: 600922; MGI: 894806; HomoloGene: 14202; GeneCards: MYLK; OMA:MYLK - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	123,884,332 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	34,822,790 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; saphenous vein; ; seminal vesicula; ; nipple; ; urethra; ; vena cava; ; superficial temporal artery; ; myometrium; ; caput epididymis; ; corpus epididymis;
	Top expressed in
	iris; ; ascending aorta; ; umbilical cord; ; migratory enteric neural crest cell; ; uterus; ; aortic valve; ; tunica media of zone of aorta; ; ciliary body; ; cervix; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; calmodulin binding; myosin light chain kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; actin binding; ATP binding;
Cellular component	cytoplasm; cytosol; cell projection; stress fiber; cleavage furrow; cytoskeleton; lamellipodium; plasma membrane; actin cytoskeleton;
Biological process	smooth muscle contraction; muscle contraction; phosphorylation; tonic smooth muscle contraction; positive regulation of cell migration; positive regulation of wound healing; bleb assembly; cellular hypotonic response; protein phosphorylation; aorta smooth muscle tissue morphogenesis; positive regulation of calcium ion transport;
	Sources:Amigo / QuickGO
Orthologs
	4638
	107589
	ENSG00000065534
	ENSMUSG00000022836
	Q15746
	Q6PDN3
NM_001321309; NM_005965; NM_053025; NM_053026; NM_053027;
	NM_053028; NM_053029; NM_053030; NM_053031; NM_053032
	NM_139300
NP_001308238; NP_444253; NP_444254; NP_444255; NP_444256;
	NP_444259; NP_444260
	NP_647461; NP_001395190; NP_001395191; NP_001395192
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065534 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022836 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG (Mar 1996). "The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21". Genomics. 29 (3): 562–70. doi:10.1006/geno.1995.9965. PMID 8575746.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065534 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022836 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8575746-5] Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG (Mar 1996). "The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21". Genomics. 29 (3): 562–70. doi:10.1006/geno.1995.9965. PMID 8575746.

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