MYLK2

MYLK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LV6, 3KF9
Identifiers
Aliases	MYLK2, KMLC, MLCK, MLCK2, skMLCK, myosin light chain kinase 2
External IDs	OMIM: 606566; MGI: 2139434; HomoloGene: 13223; GeneCards: MYLK2; OMA:MYLK2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	31,834,689 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,764,988 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; vastus lateralis muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; tibialis anterior muscle; ; deltoid muscle; ; body of pancreas; ; testicle;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; medial head of gastrocnemius muscle; ; digastric muscle; ; tibialis anterior muscle; ; knee joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calmodulin binding; myosin light chain kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; calmodulin-dependent protein kinase activity; ATP binding; myosin light chain binding;
Cellular component	cytoplasm; sarcomere; nucleus;
Biological process	regulation of muscle filament sliding; cardiac muscle contraction; phosphorylation; cardiac muscle tissue morphogenesis; skeletal muscle satellite cell differentiation; protein phosphorylation; neuromuscular synaptic transmission; positive regulation of gene expression; skeletal muscle cell differentiation; protein autophosphorylation; peptidyl-threonine phosphorylation; striated muscle contraction; peptidyl-serine phosphorylation; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	85366
	228785
	ENSG00000101306
	ENSMUSG00000027470
	Q9H1R3
	Q8VCR8
	NM_033118
	NM_001081044
	NP_149109
	NP_001074513
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101306 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davis JS, Hassanzadeh S, Winitsky S, Lin H, Satorius C, Vemuri R, Aletras AH, Wen H, Epstein ND (November 2001). "The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation". Cell. 107 (5): 631–41. doi:10.1016/S0092-8674(01)00586-4. PMID 11733062. S2CID 778253.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101306 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027470 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11733062-5] Davis JS, Hassanzadeh S, Winitsky S, Lin H, Satorius C, Vemuri R, Aletras AH, Wen H, Epstein ND (November 2001). "The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation". Cell. 107 (5): 631–41. doi:10.1016/S0092-8674(01)00586-4. PMID 11733062. S2CID 778253.

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