MYLK3

MYLK3
Identifiers
Aliases	MYLK3, MLCK, MLCK2, caMLCK, myosin light chain kinase 3
External IDs	OMIM: 612147; MGI: 2443063; HomoloGene: 35278; GeneCards: MYLK3; OMA:MYLK3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	46,790,407 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	86,112,974 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; right ventricle; ; myocardium of left ventricle; ; right auricle; ; Skeletal muscle tissue of biceps brachii; ; body of tongue; ; apex of heart; ; thoracic diaphragm; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle;
	Top expressed in
	myocardium of ventricle; ; atrium; ; interventricular septum; ; atrioventricular valve; ; epithelium of small intestine; ; esophagus; ; migratory enteric neural crest cell; ; endocardial cushion; ; left ventricle; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	calmodulin-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity; ATP binding; myosin light chain kinase activity;
Cellular component	cytoplasm; actin cytoskeleton; cytosol; intracellular anatomical structure;
Biological process	protein phosphorylation; positive regulation of sarcomere organization; regulation of vascular permeability involved in acute inflammatory response; sarcomere organization; cellular response to interleukin-1; phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction; sarcomerogenesis; cardiac myofibril assembly;
	Sources:Amigo / QuickGO
Orthologs
	91807
	213435
	ENSG00000140795
	ENSMUSG00000031698
	Q32MK0
	Q3UIZ8
	NM_001308301; NM_182493
	NM_001297612; NM_175441
	NP_001295230; NP_872299
	NP_001284541; NP_780650
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140795 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031698 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MLCK MLCK protein".
^ Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424. PMID 17885681.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140795 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MLCK MLCK protein".

[pmid17885681-6] Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424. PMID 17885681.

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