MYO10

MYO10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYO10, myosin X, MyoX
External IDsOMIM: 601481; MGI: 107716; HomoloGene: 36328; GeneCards: MYO10; OMA:MYO10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

4651

17909

Ensembl

ENSG00000145555

ENSMUSG00000022272

UniProt

Q9HD67

F8VQB6

RefSeq (mRNA)

NM_012334

NM_019472
NM_001353141
NM_001353142

RefSeq (protein)

NP_036466

NP_062345
NP_001340070
NP_001340071

Location (UCSC)Chr 5: 16.66 – 16.94 MbChr 15: 25.62 – 25.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin X, also known as MYO10, is a protein that in humans is encoded by the MYO10 gene.[5][6][7][8]

Myo10 is an actin-based motor protein that can localize to the tips of the finger-like cellular protrusions known as filopodia.[9][10] Myo10 is broadly expressed in mammalian tissues, although at relatively low levels.[8] Studies with knockout mice demonstrate that Myo10 has important functions in embryonic processes such as neural tube closure and eye development.[11][12][13] Myo10 also has important functions in cancer invasion and growth.[14][15][9][12][16][17]

Myo10 should not be confused with Myh10, which encodes the heavy chain of the class II myosin known as non-muscle myosin 2b.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145555 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022272 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MYO10 myosin X".
  6. ^ Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (July 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
  7. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
  8. ^ a b Berg JS, Derfler BH, Pennisi CM, Corey DP, Cheney RE (October 2000). "Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin". Journal of Cell Science. 113. 113 Pt 19 (19): 3439–51. doi:10.1242/jcs.113.19.3439. PMID 10984435.
  9. ^ a b Courson DS, Cheney RE (May 2015). "Myosin-X and disease". Experimental Cell Research. 334 (1): 10–5. doi:10.1016/j.yexcr.2015.03.014. PMC 4433855. PMID 25819274.
  10. ^ Tokuo H (2020). "Myosin X". Myosins. Advances in Experimental Medicine and Biology. Vol. 1239. pp. 391–403. doi:10.1007/978-3-030-38062-5_17. ISBN 978-3-030-38061-8. PMID 32451868. S2CID 218892501.
  11. ^ Heimsath EG, Yim YI, Mustapha M, Hammer JA, Cheney RE (December 2017). "Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation". Scientific Reports. 7 (1): 17354. Bibcode:2017NatSR...717354H. doi:10.1038/s41598-017-17638-x. PMC 5725431. PMID 29229982.
  12. ^ a b Tokuo H, Bhawan J, Coluccio LM (July 2018). "Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis". Scientific Reports. 8 (1): 10449. Bibcode:2018NatSR...810449T. doi:10.1038/s41598-018-28717-y. PMC 6041326. PMID 29993000.
  13. ^ Bachg AC, Horsthemke M, Skryabin BV, Klasen T, Nagelmann N, Faber C, et al. (January 2019). "Phenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X". Scientific Reports. 9 (1): 597. Bibcode:2019NatSR...9..597B. doi:10.1038/s41598-018-37160-y. PMC 6345916. PMID 30679680.
  14. ^ Arjonen A, Kaukonen R, Mattila E, Rouhi P, Högnäs G, Sihto H, et al. (March 2014). "Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis". The Journal of Clinical Investigation. 124 (3): 1069–82. doi:10.1172/JCI67280. PMC 3934176. PMID 24487586.
  15. ^ Cao R, Chen J, Zhang X, Zhai Y, Qing X, Xing W, et al. (July 2014). "Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis". British Journal of Cancer. 111 (3): 539–50. doi:10.1038/bjc.2014.298. PMC 4119973. PMID 24921915.
  16. ^ Kenchappa RS, Mistriotis P, Wisniewski E, Bhattacharya S, Kulkarni T, West R, et al. (December 2020). "Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma". iScience. 23 (12): 101802. Bibcode:2020iSci...23j1802K. doi:10.1016/j.isci.2020.101802. PMC 7702012. PMID 33299973.
  17. ^ Summerbell ER, Mouw JK, Bell JS, Knippler CM, Pedro B, Arnst JL, et al. (July 2020). "Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning". Science Advances. 6 (30): eaaz6197. Bibcode:2020SciA....6.6197S. doi:10.1126/sciadv.aaz6197. PMC 7439406. PMID 32832657.