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Macuspana is a city in Macuspana Municipality in the south-central part of the state of Tabasco in southeastern Mexico. The city of Macuspana had a 2005 census population of 30,661 and is the fifth-largest city in the state. It is the municipal seat of the municipality of Macuspana, which has an area of 2,551.7 km2 (985.22 sq mi) and a population of 142,954, which includes numerous smaller communities. The largest of these communities is Benito Juárez (San Carlos).
It is the birthplace of Andrés Manuel López Obrador, the current Mexican President.