Madoff is a surname. Notable people with the surname include:
- Bernie Madoff (1938–2021), American criminal whose US$65 billion Ponzi scheme employed many family members, including:
- Ruth Madoff (born 1941), American bookkeeper and wife of Bernie Madoff
- Mark Madoff (1964–2010), American financier and son of Bernie Madoff
- Andrew Madoff (1966–2014), American financier and son of Bernie Madoff
- Shana Madoff (born 1967), American attorney and niece of Bernie Madoff
- Michelle Madoff (1928–2013), American politician; Pittsburgh councilwoman from 1978 to 1993