The Madrean Region (named after the Sierra Madre Occidental) is a floristic region within the Holarctic Kingdom in North America, as delineated by Armen Takhtajan and Robert F. Thorne. It occupies arid or semiarid areas in the southwestern United States and northwestern Mexico and is bordered by the Rocky Mountain Floristic Region and North American Atlantic Region of the Holarctic Kingdom in the north and in the east, Caribbean Region of the Neotropical Kingdom in the south.
The Madrean Region is characterized by a very distinct flora with at least three endemic families (Fouquieriaceae, Simmondsiaceae, and Setchellanthaceae). Crossosomataceae, Garryaceae, Lennoaceae, Limnanthaceae and Stegnospermataceae have their principal development here; for Onagraceae, Polemoniaceae and Hydrophyllaceae it is the major center of diversity. More than 250 genera and probably more than half of the species of the region are endemic to it according to Takhtajan.