The Columbus to Chicago Main Line was a rail line owned and operated by the Pennsylvania Railroad in the U.S. states of Ohio, Indiana, and Illinois. The line ran from Columbus, Ohio northwest via Logansport, Indiana to Chicago, Illinois.[1] Junctions included the Columbus to Indianapolis Main Line via Bradford, which split at Bradford to reach the Pittsburgh to St. Louis Main Line at New Paris, Ohio; the Fort Wayne Branch at Ridgeville, Indiana; the Richmond Branch (from Cincinnati) at Anoka, Indiana; and the South Bend Branch and I&F Branch at Logansport.
The line has largely been abandoned. The Norfolk Southern Railway operates the portion from Redkey, Indiana west to Sweetser as the Red Key Secondary, and a short piece from Schererville, Indiana, to Hartsdale, Indiana, as the Logansport Secondary. The portion from Anoka to Logansport is part of the Winamac Southern Railway.[citation needed]