Major basic protein

PRG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H8U, 2BRS, 4QXX
Identifiers
Aliases	PRG2, BMPG, MBP, MBP1, proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein), proMBP, proteoglycan 2, pro eosinophil major basic protein
External IDs	OMIM: 605601; MGI: 103294; HomoloGene: 2044; GeneCards: PRG2; OMA:PRG2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	57,390,650 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	84,813,976 bp
RNA expression pattern
	Top expressed in
	placenta; ; bone marrow; ; bone marrow cells; ; right lobe of liver; ; skin of leg; ; subcutaneous adipose tissue; ; spleen; ; skin of abdomen; ; monocyte; ; blood;
	Top expressed in
	tibiofemoral joint; ; granulocyte; ; fetal liver hematopoietic progenitor cell; ; bone marrow; ; embryo; ; embryo; ; ankle joint; ; spleen; ; human fetus; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; carbohydrate binding; extracellular matrix structural constituent conferring compression resistance;
Cellular component	extracellular region; transport vesicle; cytoplasmic vesicle; extracellular exosome; ficolin-1-rich granule lumen; collagen-containing extracellular matrix;
Biological process	defense response to bacterium; immune system process; defense response to nematode; negative regulation of interleukin-10 production; positive regulation of interleukin-4 production; immune response; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5553
	19074
	ENSG00000186652
	ENSMUSG00000027073
	P13727
	Q61878
	NM_002728; NM_001243245; NM_001302926; NM_001302927
	NM_008920
	NP_001230174; NP_001289855; NP_001289856; NP_002719
	NP_032946
	Wikidata
View/Edit Human	View/Edit Mouse

Eosinophil major basic protein, often shortened to major basic protein (MBP; also called Proteoglycan 2 (PRG2)) is encoded in humans by the PRG2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186652 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027073 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186652 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027073 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)".

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