Manfredonia Cathedral (Italian: Duomo di Manfredonia, Cattedrale di San Lorenzo Maiorano) is a Roman Catholic cathedral in Manfredonia in Italy, dedicated to Saint Laurence of Siponto (Italian: Lorenzo Maiorano, "Laurence Majoranus"), one of the patron saints of the city. Formerly the archiepiscopal seat of the Archdiocese of Siponto, later known as Manfredonia, it is now the seat of the Archbishop of Manfredonia-Vieste-San Giovanni Rotondo.