Manius Acilius Glabrio was a plebeian Roman politician and general during the Republican. He served as consul in 191 BC while Rome was at war with the Seleucid Empire. He defeated Emperor Antiochus the Great at Thermopylae, helping establish Roman unipolar control over the Mediterranean, and was awarded a triumph. Credible accusations that he had embezzled spoils from his conquests in Greece while consul caused him to withdraw from his attempt to run for censor, after which he largely retired from public life.
He and his son—who later served as suffect consul—were responsible for the construction of Rome's Temple of Piety beside the Forum Olitorium. One of its decorations was a gilt statue of Acilius Glabrio, the first such golden statue of a citizen in Rome.