Mannose 6-phosphate receptor

Cation-independent mannose-6-phosphate receptor repeat
Identifiers
SymbolCIMR
PfamPF00878
InterProIPR000479
SCOP21e6f / SCOPe / SUPFAM
Membranome30
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Cation-dependent mannose-6-phosphate receptor
Identifiers
SymbolM6PR
NCBI gene4074
HGNC6752
OMIM154540
RefSeqNM_002355
UniProtP20645
Other data
LocusChr. 12 p13
Search for
StructuresSwiss-model
DomainsInterPro
Cation-independent mannose-6 phosphate receptor
Identifiers
SymbolIGF2R
NCBI gene3482
HGNC5467
OMIM147280
RefSeqNM_000876
UniProtP11717
Other data
LocusChr. 6 q25q27
Search for
StructuresSwiss-model
DomainsInterPro

The mannose 6-phosphate receptors (MPRs) are transmembrane glycoproteins that target enzymes to lysosomes in vertebrates.[1]

Mannose 6-phosphate receptors bind newly synthesized lysosomal hydrolases in the trans-Golgi network (TGN) and deliver them to pre-lysosomal compartments. There are two different MPRs, one of ~300kDa and a smaller, dimeric receptor of ~46kDa.[2][3] The larger receptor is known as the cation-independent mannose 6-phosphate receptor (CI-MPR), while the smaller receptor (CD-MPR) requires divalent cations to efficiently recognize lysosomal hydrolases.[3] While divalent cations are not essential for ligand binding by the human CD-MPR, the nomenclature has been retained.[4]

Both of these receptors bind terminal mannose 6-phosphate with similar affinity (CI-MPR = 7 μM, CD-MPR = 8 μM)[5] and have similar signals in their cytoplasmic domains for intracellular trafficking.[6]

  1. ^ Drickamer K, Taylor ME (2011). Introduction to glycobiology (3rd ed.). Oxford [u.a.]: Oxford University Press. pp. 177–181. ISBN 978-0199569113.
  2. ^ Hoflack B, Kornfeld S (July 1985). "Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-kDa mannose 6-phosphate receptor: evidence for the existence of a second mannose 6-phosphate receptor". Proc. Natl. Acad. Sci. U.S.A. 82 (13): 4428–32. Bibcode:1985PNAS...82.4428H. doi:10.1073/pnas.82.13.4428. PMC 391114. PMID 3160044.
  3. ^ a b Hoflack B, Kornfeld S (October 1985). "Purification and characterization of a cation-dependent mannose 6-phosphate receptor from murine P388D1 macrophages and bovine liver". J. Biol. Chem. 260 (22): 12008–14. doi:10.1016/S0021-9258(17)38977-9. PMID 2931431.
  4. ^ Junghans U, Waheed A, von Figura K (September 1988). "The 'cation-dependent' mannose 6-phosphate receptor binds ligands in the absence of divalent cations". FEBS Lett. 237 (1–2): 81–4. doi:10.1016/0014-5793(88)80176-5. PMID 2971570. S2CID 29141433.
  5. ^ Tong PY, Kornfeld S (May 1989). "Ligand interactions of the cation-dependent mannose 6-phosphate receptor. Comparison with the cation-independent mannose 6-phosphate receptor". J. Biol. Chem. 264 (14): 7970–5. doi:10.1016/S0021-9258(18)83137-4. PMID 2542255.
  6. ^ Johnson KF, Chan W, Kornfeld S (December 1990). "Cation-dependent mannose 6-phosphate receptor contains two internalization signals in its cytoplasmic domain". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 10010–4. Bibcode:1990PNAS...8710010J. doi:10.1073/pnas.87.24.10010. PMC 55304. PMID 2175900.