Greek-born computational biologist
Manolis Kellis (Greek : Μανώλης Καμβυσέλλης ; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard .[ 3] He is the head of the Computational Biology Group at MIT[ 4] and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.[ 5]
Kellis is known for his contributions to genomics , human genetics , epigenomics , gene regulation , genome evolution , disease mechanism , and single-cell genomics . He co-led the NIH Roadmap Epigenomics Project[ 6] effort to create a comprehensive map of the human epigenome,[ 7] [ 8] [ 9] the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome,[ 10] [ 11] the ENCODE , GENCODE , and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms.[ 12] [ 13] [ 14] A major focus of his work is understanding the effects of genetic variations on human disease,[ 15] with contributions to obesity,[ 16] [ 17] [ 18] diabetes,[ 19] Alzheimer's disease,[ 20] [ 21] [ 22] schizophrenia,[ 23] and cancer.[ 24]
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^ Kamvysselis, Manolis (2003). Computational comparative genomics : genes, regulation, evolution (PhD thesis). MIT. hdl :1721.1/7999 . OCLC 53277177 .
^ "Manolis Kellis | MIT CSAIL" . www.csail.mit.edu . Retrieved 2018-07-19 .
^ "MIT Computational Biology Group" . MIT Computational Biology Group Lab Head . Retrieved 2018-07-19 .
^ Kellis, Manolis. "People | MIT CSAIL" . www.csail.mit.edu . Retrieved 2018-07-19 .
^ "Roadmap Epigenomics Project - Home" . www.roadmapepigenomics.org . Retrieved 2018-07-24 .
^ Cite error: The named reference :1
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^ "Researchers generate a reference map of the human epigenome" . MIT News . Retrieved 2018-07-18 .
^ "Researchers generate a reference map of the human epigenome" . MIT News . Retrieved 2018-07-19 .
^ Lindblad-Toh, Kerstin; Garber, Manuel; Zuk, Or; Lin, Michael F.; Parker, Brian J.; Washietl, Stefan; Kheradpour, Pouya; Ernst, Jason; Kellis, Manolis (2011). "A high-resolution map of human evolutionary constraint using 29 mammals" . Nature . 478 (7370): 476–482. Bibcode :2011Natur.478..476. . doi :10.1038/nature10530 . ISSN 0028-0836 . PMC 3207357 . PMID 21993624 .
^ "Analysis of 29 mammals reveals genomic 'dark matter' " . MIT News . Retrieved 2018-07-21 .
^ Kellis, Manolis; Wold, Barbara; Snyder, Michael P.; Bernstein, Bradley E.; Kundaje, Anshul; Marinov, Georgi K.; Ward, Lucas D.; Birney, Ewan; Crawford, Gregory E. (2014-04-29). "Defining functional DNA elements in the human genome" . Proceedings of the National Academy of Sciences . 111 (17): 6131–6138. Bibcode :2014PNAS..111.6131K . doi :10.1073/pnas.1318948111 . ISSN 0027-8424 . PMC 4035993 . PMID 24753594 .
^ Ernst, Jason; Kheradpour, Pouya; Mikkelsen, Tarjei S.; Shoresh, Noam; Ward, Lucas D.; Epstein, Charles B.; Zhang, Xiaolan; Wang, Li; Issner, Robbyn (2011-03-23). "Mapping and analysis of chromatin state dynamics in nine human cell types" . Nature . 473 (7345): 43–49. Bibcode :2011Natur.473...43E . doi :10.1038/nature09906 . ISSN 0028-0836 . PMC 3088773 . PMID 21441907 .
^ Consortium, The modENCODE; Roy, Sushmita; Ernst, Jason; Kharchenko, Peter V.; Kheradpour, Pouya; Negre, Nicolas; Eaton, Matthew L.; Landolin, Jane M.; Bristow, Christopher A. (2010-12-24). "Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE" . Science . 330 (6012): 1787–1797. Bibcode :2010Sci...330.1787R . doi :10.1126/science.1198374 . ISSN 0036-8075 . PMC 3192495 . PMID 21177974 .
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^ "Identifying the gene switch that turns fat cells bad" . Science | AAAS . 2015-08-19. Retrieved 2018-07-19 .
^ "A Fat-Burning Gene May Help Weight Loss" . Time . Retrieved 2018-07-19 .
^ Claussnitzer, Melina; Dankel, Simon N.; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S.; Kellis, Manolis (2015-09-03). "FTO Obesity Variant Circuitry and Adipocyte Browning in Humans" . New England Journal of Medicine . 373 (10): 895–907. doi :10.1056/nejmoa1502214 . ISSN 0028-4793 . PMC 4959911 . PMID 26287746 .
^ Onengut-Gumuscu, Suna; Chen, Wei-Min; Burren, Oliver; Cooper, Nick J; Quinlan, Aaron R; Mychaleckyj, Josyf C; Farber, Emily; Bonnie, Jessica K; Kellis, Manolis (2015-03-09). "Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers" . Nature Genetics . 47 (4): 381–386. doi :10.1038/ng.3245 . ISSN 1061-4036 . PMC 4380767 . PMID 25751624 .
^ Gjoneska, Elizabeta; Pfenning, Andreas R.; Mathys, Hansruedi; Quon, Gerald; Kundaje, Anshul; Tsai, Li-Huei; Kellis, Manolis (2015). "Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease" . Nature . 518 (7539): 365–369. Bibcode :2015Natur.518..365G . doi :10.1038/nature14252 . ISSN 0028-0836 . PMC 4530583 . PMID 25693568 .
^ "Epigenomics of Alzheimer's disease progression" . MIT News . Retrieved 2018-07-19 .
^ "Manolis Kellis – Cure Alzheimer's Fund" . Cure Alzheimer's Fund . Retrieved 2018-07-19 .
^ Manolis, Kellis; Mark, Daly; Kevin, Eggan; Alkes, Price. "NIH Grant, Network-based prediction and validation of causal schizophrenia genes and variants" . Grantome .
^ Hornshøj, Henrik; Nielsen, Morten Muhlig; Sinnott-Armstrong, Nicholas A.; Świtnicki, Michał P.; Juul, Malene; Madsen, Tobias; Sallari, Richard; Kellis, Manolis; Ørntoft, Torben (2018-01-11). "Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival" . npj Genomic Medicine . 3 (1): 1. doi :10.1038/s41525-017-0040-5 . ISSN 2056-7944 . PMC 5765157 . PMID 29354286 .