Manolis Kellis

Manolis Kellis
Manolis Kellis at the American Society of Human Genetics (ASHG) meeting in Orlando Florida on October 19, 2017
Born
Manolis Kamvysellis
Greek: Μανώλης Καμβυσέλλης

(1977-03-13) March 13, 1977 (age 47)
Athens, Greece
Alma materMassachusetts Institute of Technology (PhD)
Known forENCODE
Awards
Scientific career
Fields
ThesisComputational Comparative Genomics: Genes, Regulation, Evolution. (2003)
Doctoral advisor
Websitecompbio.mit.edu

Manolis Kellis (Greek: Μανώλης Καμβυσέλλης; born 1977) is a professor of Computer Science and Computational Biology at the Massachusetts Institute of Technology (MIT) and a member of the Broad Institute of MIT and Harvard.[3] He is the head of the Computational Biology Group at MIT[4] and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.[5]

Kellis is known for his contributions to genomics, human genetics, epigenomics, gene regulation, genome evolution, disease mechanism, and single-cell genomics. He co-led the NIH Roadmap Epigenomics Project[6] effort to create a comprehensive map of the human epigenome,[7][8][9] the comparative analysis of 29 mammals to create a comprehensive map of conserved elements in the human genome,[10][11] the ENCODE, GENCODE, and modENCODE projects to characterize the genes, non-coding elements, and circuits of the human genome and model organisms.[12][13][14] A major focus of his work is understanding the effects of genetic variations on human disease,[15] with contributions to obesity,[16][17][18] diabetes,[19] Alzheimer's disease,[20][21][22] schizophrenia,[23] and cancer.[24]

  1. ^ Cite error: The named reference gs was invoked but never defined (see the help page).
  2. ^ Kamvysselis, Manolis (2003). Computational comparative genomics : genes, regulation, evolution (PhD thesis). MIT. hdl:1721.1/7999. OCLC 53277177. Free access icon
  3. ^ "Manolis Kellis | MIT CSAIL". www.csail.mit.edu. Retrieved 2018-07-19.
  4. ^ "MIT Computational Biology Group". MIT Computational Biology Group Lab Head. Retrieved 2018-07-19.
  5. ^ Kellis, Manolis. "People | MIT CSAIL". www.csail.mit.edu. Retrieved 2018-07-19.
  6. ^ "Roadmap Epigenomics Project - Home". www.roadmapepigenomics.org. Retrieved 2018-07-24.
  7. ^ Cite error: The named reference :1 was invoked but never defined (see the help page).
  8. ^ "Researchers generate a reference map of the human epigenome". MIT News. Retrieved 2018-07-18.
  9. ^ "Researchers generate a reference map of the human epigenome". MIT News. Retrieved 2018-07-19.
  10. ^ Lindblad-Toh, Kerstin; Garber, Manuel; Zuk, Or; Lin, Michael F.; Parker, Brian J.; Washietl, Stefan; Kheradpour, Pouya; Ernst, Jason; Kellis, Manolis (2011). "A high-resolution map of human evolutionary constraint using 29 mammals". Nature. 478 (7370): 476–482. Bibcode:2011Natur.478..476.. doi:10.1038/nature10530. ISSN 0028-0836. PMC 3207357. PMID 21993624.
  11. ^ "Analysis of 29 mammals reveals genomic 'dark matter'". MIT News. Retrieved 2018-07-21.
  12. ^ Kellis, Manolis; Wold, Barbara; Snyder, Michael P.; Bernstein, Bradley E.; Kundaje, Anshul; Marinov, Georgi K.; Ward, Lucas D.; Birney, Ewan; Crawford, Gregory E. (2014-04-29). "Defining functional DNA elements in the human genome". Proceedings of the National Academy of Sciences. 111 (17): 6131–6138. Bibcode:2014PNAS..111.6131K. doi:10.1073/pnas.1318948111. ISSN 0027-8424. PMC 4035993. PMID 24753594.
  13. ^ Ernst, Jason; Kheradpour, Pouya; Mikkelsen, Tarjei S.; Shoresh, Noam; Ward, Lucas D.; Epstein, Charles B.; Zhang, Xiaolan; Wang, Li; Issner, Robbyn (2011-03-23). "Mapping and analysis of chromatin state dynamics in nine human cell types". Nature. 473 (7345): 43–49. Bibcode:2011Natur.473...43E. doi:10.1038/nature09906. ISSN 0028-0836. PMC 3088773. PMID 21441907.
  14. ^ Consortium, The modENCODE; Roy, Sushmita; Ernst, Jason; Kharchenko, Peter V.; Kheradpour, Pouya; Negre, Nicolas; Eaton, Matthew L.; Landolin, Jane M.; Bristow, Christopher A. (2010-12-24). "Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE". Science. 330 (6012): 1787–1797. Bibcode:2010Sci...330.1787R. doi:10.1126/science.1198374. ISSN 0036-8075. PMC 3192495. PMID 21177974.
  15. ^ Cite error: The named reference :2 was invoked but never defined (see the help page).
  16. ^ "Identifying the gene switch that turns fat cells bad". Science | AAAS. 2015-08-19. Retrieved 2018-07-19.
  17. ^ "A Fat-Burning Gene May Help Weight Loss". Time. Retrieved 2018-07-19.
  18. ^ Claussnitzer, Melina; Dankel, Simon N.; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S.; Kellis, Manolis (2015-09-03). "FTO Obesity Variant Circuitry and Adipocyte Browning in Humans". New England Journal of Medicine. 373 (10): 895–907. doi:10.1056/nejmoa1502214. ISSN 0028-4793. PMC 4959911. PMID 26287746.
  19. ^ Onengut-Gumuscu, Suna; Chen, Wei-Min; Burren, Oliver; Cooper, Nick J; Quinlan, Aaron R; Mychaleckyj, Josyf C; Farber, Emily; Bonnie, Jessica K; Kellis, Manolis (2015-03-09). "Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers". Nature Genetics. 47 (4): 381–386. doi:10.1038/ng.3245. ISSN 1061-4036. PMC 4380767. PMID 25751624.
  20. ^ Gjoneska, Elizabeta; Pfenning, Andreas R.; Mathys, Hansruedi; Quon, Gerald; Kundaje, Anshul; Tsai, Li-Huei; Kellis, Manolis (2015). "Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease". Nature. 518 (7539): 365–369. Bibcode:2015Natur.518..365G. doi:10.1038/nature14252. ISSN 0028-0836. PMC 4530583. PMID 25693568.
  21. ^ "Epigenomics of Alzheimer's disease progression". MIT News. Retrieved 2018-07-19.
  22. ^ "Manolis Kellis – Cure Alzheimer's Fund". Cure Alzheimer's Fund. Retrieved 2018-07-19.
  23. ^ Manolis, Kellis; Mark, Daly; Kevin, Eggan; Alkes, Price. "NIH Grant, Network-based prediction and validation of causal schizophrenia genes and variants". Grantome.
  24. ^ Hornshøj, Henrik; Nielsen, Morten Muhlig; Sinnott-Armstrong, Nicholas A.; Świtnicki, Michał P.; Juul, Malene; Madsen, Tobias; Sallari, Richard; Kellis, Manolis; Ørntoft, Torben (2018-01-11). "Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival". npj Genomic Medicine. 3 (1): 1. doi:10.1038/s41525-017-0040-5. ISSN 2056-7944. PMC 5765157. PMID 29354286.