Manuel Kantakouzenos (or Cantacuzenus) (Greek: Μανουήλ Καντακουζηνός, Manouēl Kantakouzēnos), (c. 1326 – Mistra, Peloponnese, 10 April 1380) was the despotēs in the Despotate of Morea or the Peloponnese from 25 October 1349 to his death.