| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | TRAIL-receptor (death receptor 4) |
| Clinical data | |
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| CAS Number | |
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| Chemical and physical data | |
| Formula | C6748H10408N1800O2092S52 |
| Molar mass | 151891.12 g·mol−1 |
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Mapatumumab (HGS-ETR1) is an experimental human monoclonal antibody undergoing clinical trials for the treatment of cancer.[1] It targets TRAIL-R1, also known as DR4, which is expressed on the surface of many tumor cell types.[2]
- ^ Statement On A Nonproprietary Name Adopted By The Usan Council - Mapatumumab, American Medical Association.
- ^ Moretto P, Hotte SJ (March 2009). "Targeting apoptosis: preclinical and early clinical experience with mapatumumab, an agonist monoclonal antibody targeting TRAIL-R1". Expert Opinion on Investigational Drugs. 18 (3): 311–25. doi:10.1517/13543780902752463. PMID 19243282. S2CID 71176481.