| Margaret Paleologa | |
|---|---|
 Portrait by Giulio Romano believed to depict Margaret Paleologa, c.1531. The Royal Collection. | |
| Marquise of Montferrat | |
| Reign | 1533–1536 |
| Predecessor | John Georg Palaiologos |
| Successor | Federico II Gonzaga |
| Born | 11 August 1510 Casale Monferrato |
| Died | 28 December 1566 (aged 56) Mantua, Duchy of Mantua |
| Spouse | Federico II Gonzaga, Duke of Mantua |
| Issue | Francesco III Gonzaga, Duke of Mantua
Isabella Gonzaga Guglielmo Gonzaga, Duke of Mantua Louis Gonzaga, Duke of Nevers Federico Gonzaga (cardinal) |
| House | Palaeologus-Montferrat |
| Father | William IX of Montferrat |
| Mother | Anne of Alençon |
| Religion | Roman Catholicism |
Margaret Palaeologa (Italian: Margherita Paleologa; 11 August 1510 in Casale Monferrato – 28 December 1566 in Mantua), was the ruling Marquise regnant of Montferrat in her own right between 1533 and 1536. She was also Duchess of Mantua by marriage to Federico II, Duke of Mantua. Margaret acted as the regent of the Duchy of Mantua twice during the minority of her sons: for her elder son Francesco III Gonzaga, Duke of Mantua in 1540-1549, and for her younger son Guglielmo Gonzaga, Duke of Mantua, between 1550 and 1556.