Margaret of Antioch-Lusignan (French: Marguerite; c. 1244 - 30 January 1308), also known as Margaret of Tyre, was an Outremer noblewoman who ruled the Lordship of Tyre in the Kingdom of Jerusalem. A member of the House of Antioch-Lusignan, she married John of Montfort, Lord of Tyre, and was granted rule of the city as widow in 1284. She concluded a truce with the Egyptian sultan Al-Mansur Qalawun and ruled until 1291, when she ceded the lordship and moved to Cyprus.