| Margherita Maria Farnese | |
|---|---|
| Duchess of Modena and Reggio | |
| Born | 24 November 1664 Parma |
| Died | 17 June 1718 (aged 53) Ducal Palace of Colorno, Colorno |
| Burial | |
| Spouse | Francesco II d'Este, Duke of Modena |
| Father | Ranuccio II Farnese, Duke of Parma |
| Mother | Isabella d'Este |
Margherita Maria Farnese (24 November 1664 – 17 June 1718) was an Italian noblewoman born into the House of Farnese. She was the Duchess of Modena and Reggio by marriage to her first cousin Francesco II d'Este, Duke of Modena. Her niece was Elisabeth Farnese, wife of Philip V of Spain.