Maria Louisa may refer to:
- Maria Louisa Angwin (1849–1898), Canadian physician
- Maria Louisa Bustill (1853–1904), American schoolteacher
- Maria Louisa Charlesworth (1819–1880), English religious author
- Maria Louisa Pike (d. 1892), American naturalist
- Maria Louisa Walsworth (1822–1859), American missionary