Maribavir

Maribavir
Clinical data
Trade namesLivtencity
Other names1263W94
AHFS/Drugs.comMonograph
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
  • (2S,3S,4R,5S)-2-[5,6-Dichloro-2-(propan-2-ylamino)benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H19Cl2N3O4
Molar mass376.23 g·mol−1
3D model (JSmol)
  • CC(C)Nc1nc2cc(c(cc2n1[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)O)Cl)Cl
  • InChI=1S/C15H19Cl2N3O4/c1-6(2)18-15-19-9-3-7(16)8(17)4-10(9)20(15)14-13(23)12(22)11(5-21)24-14/h3-4,6,11-14,21-23H,5H2,1-2H3,(H,18,19)/t11-,12-,13-,14-/m0/s1 ☒N
  • Key:KJFBVJALEQWJBS-XUXIUFHCSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Maribavir, sold under the brand name Livtencity, is an antiviral medication that is used to treat post-transplant cytomegalovirus (CMV).[8][9] Maribavir is a cytomegalovirus pUL97 kinase inhibitor that works by preventing the activity of human cytomegalovirus enzyme pUL97, thus blocking virus replication.[9]

The most common side effects include taste disturbance, nausea, diarrhea, vomiting and fatigue.[9]

Maribavir was approved for medical use in the United States in November 2021,[9][11] and in the European Union in November 2022.[10] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.[12]

  1. ^ a b "Livtencity". Therapeutic Goods Administration (TGA). 21 October 2022. Archived from the original on 5 February 2023. Retrieved 29 April 2023.
  2. ^ "Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 21 December 2022. Archived from the original on 3 April 2022. Retrieved 2 January 2023.
  3. ^ "LIVTENCITY (Takeda Pharmaceuticals Australia Pty Ltd)". Therapeutic Goods Administration (TGA). 11 November 2022. Archived from the original on 27 March 2023. Retrieved 29 April 2023.
  4. ^ "Therapeutic Goods (Poisons Standard—June 2024) Instrument 2024". Federal Register of Legislation. 30 May 2024. Retrieved 10 June 2024.
  5. ^ "Livtencity (Maribavir tablets) Product Monograph" (PDF). Health Canada. September 2022. Archived (PDF) from the original on 1 October 2022. Retrieved 29 April 2023.
  6. ^ "Livtencity Summary Basis of Decision". Health Canada. 23 October 2014. Archived from the original on 29 April 2023. Retrieved 10 March 2023.
  7. ^ "Details for: Livtencity". Health Canada. 25 October 2022. Archived from the original on 3 March 2024. Retrieved 3 March 2024.
  8. ^ a b "Livtencity- maribavir tablet, coated". DailyMed. Archived from the original on 19 December 2021. Retrieved 19 December 2021.
  9. ^ a b c d e "FDA Approves First Treatment for Common Type of Post-Transplant Infection that is Resistant to Other Drugs". U.S. Food and Drug Administration (FDA) (Press release). 23 November 2021. Archived from the original on 24 November 2021. Retrieved 23 November 2021. Public Domain This article incorporates text from this source, which is in the public domain.
  10. ^ a b Cite error: The named reference Livtencity EPAR was invoked but never defined (see the help page).
  11. ^ "Takeda's Livtencity (maribavir) Approved by U.S. FDA as the First and Only Treatment for People Ages 12 and Older with Post-Transplant Cytomegalovirus (CMV), Refractory (With or Without Genotypic Resistance) to Conventional Antiviral Therapies". Takeda (Press release). 23 November 2021. Archived from the original on 27 November 2021. Retrieved 26 November 2021.
  12. ^ Advancing Health Through Innovation: New Drug Therapy Approvals 2021 (PDF). U.S. Food and Drug Administration (FDA) (Report). 13 May 2022. Archived from the original on 6 December 2022. Retrieved 22 January 2023. Public Domain This article incorporates text from this source, which is in the public domain.