Marine Isotope Stage 5 or MIS 5 is a marine isotope stage in the geologic temperature record, between 130,000 and 80,000 years ago.[1] Sub-stage MIS 5e corresponds to the Last Interglacial, also called the Eemian (in Europe) or Sangamonian (in North America), the last major interglacial period before the Holocene, which extends to the present day.[2] Interglacial periods which occurred during the Pleistocene are investigated to better understand present and future climate variability. Thus, the present interglacial, the Holocene, is compared with MIS 5 or the interglacials of Marine Isotope Stage 11.