Molecular geneticist and Nobel laureate
Mario Ramberg Capecchi (born 6 October 1937) is an Italian-born molecular geneticist and a co-awardee of the 2007 Nobel Prize in Physiology or Medicine for discovering a method to create mice in which a specific gene is turned off, known as knockout mice .[ 1] [ 2] [ 3] [ 4] [ 5] [ 6] He shared the prize with Martin Evans and Oliver Smithies .[ 7] He is currently Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine .[ 8] [ 9] [ 10] [ 11] [ 12]
^ Skipper, Magda (2005). "An Interview With Mario Capecchi" . Nature Reviews Genetics . 6 (6): 434. doi :10.1038/nrg1647 . ISSN 1471-0056 . PMID 15934189 . S2CID 31781543 .
^ Thomas, K. R.; Capecchi, M. R. (1987). "Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells". Cell . 51 (3): 503–512. doi :10.1016/0092-8674(87)90646-5 . PMID 2822260 . S2CID 31961262 .
^ Mansour, S. L.; Thomas, K. R.; Capecchi, M. R. (1988). "Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes". Nature . 336 (6197): 348–352. Bibcode :1988Natur.336..348M . doi :10.1038/336348a0 . PMID 3194019 . S2CID 2997260 .
^ Capecchi, M. R. (1980). "High efficiency transformation by direct microinjection of DNA into cultured mammalian cells". Cell . 22 (2 Pt 2): 479–488. doi :10.1016/0092-8674(80)90358-x . PMID 6256082 . S2CID 2189404 .
^ Chisaka, O.; Capecchi, M. R. (1991). "Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5". Nature . 350 (6318): 473–479. Bibcode :1991Natur.350..473C . doi :10.1038/350473a0 . PMID 1673020 . S2CID 972118 .
^ Thomas, K. R.; Folger, K. R.; Capecchi, M. R. (1986). "High frequency targeting of genes to specific sites in the mammalian genome". Cell . 44 (3): 419–428. doi :10.1016/0092-8674(86)90463-0 . PMID 3002636 . S2CID 30570106 .
^ "The Nobel Prize in Physiology or Medicine 2007" . Nobelprize.org. Retrieved 2007-10-08 .
^ Mario Capecchi publications indexed by Microsoft Academic
^ Kain, K. (2008). "The first transgenic mice: An interview with Mario Capecchi" . Disease Models and Mechanisms . 1 (4–5): 197–201. doi :10.1242/dmm.001966 . PMC 2590805 . PMID 19093023 .
^ Cohen-Tannoudji, M. (2007). "Prix Nobel de Médecine 2007" . Médecine/Sciences . 23 (12): 1159–1161. doi :10.1051/medsci/200723121159 . PMID 18154719 .
^ Capecchi, M. (2005). "An Interview with" . Nature Reviews Genetics . 6 (6): 434. doi :10.1038/nrg1647 . PMID 15934189 . S2CID 31781543 .
^ Dennis, C. (2004). "Mario Capecchi: From rags to research" . Nature . 430 (6995): 10–11. Bibcode :2004Natur.430...10D . doi :10.1038/430010a . PMID 15229575 . S2CID 4347862 .